evaluation of changes of kidney parameteres in new zealand rabbits subsequent to 90 days exposure to uranyl nitrate in drinking water

background: this study was undertaken to examine the reversibility of renal injury in the male new zealand white rabbits sub­se­quent to a 90-days exposure to uranyl nitrate (un) in drinking water. animals were exposed for 90 days to uranyl ni­trate in their drinking water (24 or 500mg/l). control group were given municipal tap water. methods: the indicators of kidney function measured in this study included glucose (marker of tubular) microalbu­min(marker of glomerular) and marker for cell toxicity was  alkaline phosphatase. results: urinary glucose was found to be significantly different and positively correlated with uranium intake for rabbits. mi­croal­buminuria was found to be significantly different but this different is in normal range. increase of alkaline phos­phatase at weeks 2, 4, 6 was correlated with uranium intake, but at weeks 8, 10, 13 excretion of alkaline phosphatase was de­creased. conclusion: these results suggest that chronic ingestion of uranium in drinking water affect kidney function and to the proxi­mal tubule, rather than glomerul.